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Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy

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Nanoscale, 2013, Advance Article
DOI: 10.1039/C3NR00227F, Communication
Wenjing Wang, Chenjie Fang, Xiaozhu Wang, Yuxi Chen, Yaonan Wang, Wei Feng, Chunhua Yan, Ming Zhao, Shiqi Peng
Mesoporous silica nanoparticles with methotrexate and 6-mercaptopurine, 6-MP-MSNSN-MTX, were prepared, which in the presence of DTT releases 6-MP, while in rat plasma it effectively inhibits the metabolic deactivation of 6-MP and MTX.
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